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31 August 2012
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Comparison between two treatment protocols with recombinant Human Erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-Isoimmunization

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Objectve. The Rh-hemolytic disease can lead to a late anemia by hemolytic and hyporigenerative mechanism. We compared the effectiveness of rHuEPO in two care protocols that differ for doses of rHuEPO administrated and for timing of administration. Methods. A cohort of 14 neonates was investigated. The neonates were treated with two different protocols. Protocol A: a dose of 200 U/kg/day of rHuEpo administered subcutaneously starting from the end of the second week of life; Protocol B: a dose of 400 U/kg/day of rHuEpo administered subcutaneously starting from the end of the first week of life. Results. The hematocrit values in the protocol A group decreased during treatment (32,5% vs 25,2%), whereas the hematocrit value in protocol B group remained almost stable (38,7% vs 42,8%). The mean numbers of platelets remained stable in both groups while neutrophils increased in protocol A group and decreased in protocol B (p<0,05). Reticulocyte count increased during treatment in both groups, although only in protocol B group it was statistically significative (p<0,05). Conclusions. Our results suggest a similar efficacy between the two treatment protocols. Increasing doses of rHuEPO do not seem enhancing their effectiveness and the incidence of side effects.

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Robert D. Christensen (2018)
Avery's Diseases of the Newborn. , 1152.
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Robert D. Christensen (2024)
Principles of Neonatology. , 357.
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Jun Duan, Xiangyong Kong, Qiuping Li, Shaodong Hua, Sheng Zhang, Xiaoying Zhang, Zhichun Feng (2016)
Association between anemia and bronchopulmonary dysplasia in preterm infants. Scientific Reports, 6(1).
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Papel de los estimulantes de eritropoyesis en la anemia neonatal. Revista de la Facultad de Ciencias de la Salud Universidad del Cauca, 23(2), 17.
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Jacqueline F. Morrison, Ellis J. Neufeld, Rachael F. Grace (2014)
The use of erythropoietin‐stimulating agents versus supportive care in newborns with hereditary spherocytosis: a single centre's experience. European Journal of Haematology, 93(2), 161.
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CHEN-TING WEN, TAO HE, YI-QIAO XING (2014)
Erythropoietin promotes retinal angiogenesis in a mouse model. Molecular Medicine Reports, 10(6), 2979.

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Comparison between two treatment protocols with recombinant Human Erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-Isoimmunization. (2012). La Pediatria Medica E Chirurgica, 34(4). https://doi.org/10.4081/pmc.2012.72