Tue, 03 Nov 2020 in La Pediatria Medica e Chirurgica : Medical and Surgical Pediatrics
Guidelines of the Italian Society of Videosurgery in Infancy (SIVI) for the minimally invasive treatment of fetal and neonatal ovarian cysts
DOI: 10.4081/pmc.2020.242
Main Text
Background
The SIVI (Italian Society of Videosurgery in Infancy) guidelines are clinical practice guidelines edited and approved by the Society’s steering committee. They are the products of a detailed systematic review of the literature, integrated with expert opinion in the field of pediatric minimally invasive surgery. These guidelines are intended to assist the pediatric surgeons experienced or not experienced in minimally invasive surgery, with the goal to inform choices related to the indications, approach, and techniques to use when treating the major pediatric surgical pathologies.
Given the complexities of congenital malformations and other pediatric surgical conditions, as well as large variations in available regional health services, we must note that these guidelines are not intended as a cookbook recipe to follow for all possible patients. Rather, the guidelines should serve as a flexible framework, to be used by the physician in concert with the parents, to choose the best approach for each individual patient. Decisions tailored to available scientific knowledge and the needs and desires of the patient’s family serve both patient autonomy and medical science.
All guidelines are published in this scientific Journal, in order to ensure their availability to all physicians.
The Guidelines project has been approved by the SIVI General Assembly of the 2016 Madrid congress.
Review of guidelines has been performed by the Steering Committee of SIVI and experts.
Introduction
In the last three decades, fetal ovarian cysts were diagnosed more frequently, due to technological improvement and the increasing use of prenatal screening ultrasound. Nonetheless, treatment uncertainties are still present, either prenatally or postnatally. Recently, significant innovations on diagnosis and treatment have been proposed and a more conservative, minimally invasive approach may be offered to the Pediatrician or the Surgeon who face with this condition during prenatal or neonatal age.
These recommendations have been approved by the SIVI Board of Directors and are developed as a flexible guide to correctly address the Gynecologist, Pediatric Surgeon or Urologist and also the Neonatologist to choose the most appropriate treatment, selected from the updated literature and from the experience of the SIVI group of Experts.
Definition and epidemiology
The exact incidence of Fetal and Neonatal Ovarian Cysts (FNOC) is not known, usually reported as high as 1 in 1000-2500 live born.1,2 During fetal and neonatal life, ovaries are usually considered quiescent, and no consensus on the development of FNOC exists. The wider accepted theory implicates an abnormal response to maternal gonadotropin and estrogen, thought to induce follicular cysts growth and their pseudo-maturation.2,3 Enriquez and co-workers suggest a possible role of gonadic dysgenesis, secondary to vascular injury, as risk factor for development of complicated cysts.4
Generally discovered during 3rd trimester, FNOC are usually not considered pathologic if less than 20 mm in diameter, while is common the ultrasonographic incidental finding of stimulated ovaries, with cysts ranging 1 or 2 mm in diameter.
Prenatal diagnosis
Ultrasonographic appearance of SIMPLE FNOC include round, anechoic, single cyst with thin wall, usually unilateral with pelvic position.3,8 Occasionally, simple FNOC may present an internal septum, while the presence of a daughter cyst (a smaller cyst within the FNOC) is recognized as pathognomonic diagnostic sign:3,8,9 no other abdominal cystic lesions (including lymphangiomas, intestinal duplication, meconium pseudo-cyst, hydrometrocolpos or uracal cyst) were ever been reported with daughter cyst evidence9 (Figure 1).
At the ultrasonographic scan, COMPLEX FNOC are characterized by a thickened wall with heterogenic appearance: multiple septa are commonly reported, associated with debris flocculation and/or fluid-fluid level, or solid feature.3 It is often thought that complex FNOC are the result of ovarian torsion, occurring more frequently during fetal life more than neonatal period.10 In some cases, complex FNOC are associated to poly-hydramnios and/or fetal ascites, interpreted as cyst rupture or cyst exudation.11,12 Moreover, intestinal occlusions were reported secondary to necrosis of complicated FNOC developing intestinal adherences.10 Therefore, a diagnosis of complicated FNOC is commonly considered as an indication for surgical postnatal exploration3,10 (Figure 2).
Prenatal MRI
In selected cases, specifically when the ultrasonographic window is limited by maternal habitus, fetal position or important polyhydramnios, fetal MRI could be helpful. Furthermore, MRI could also be useful to confirm the presence of female genitalia, gastrointestinal and genitourinary anatomy, which are necessary in the diagnosis of fetal ovarian cysts and in their differential diagnosis.3,13
Differential diagnosis
Differential diagnosis of intra-abdominal fetal cysts is broad. Nonetheless, when is possible to establish the organ of origin, it is also possible to quickly limit the differential diagnostic entities, decisively orienting prenatal counseling, pre and postnatal treatment. 3 The main cystic lesions that must enter into differential diagnosis with fetal ovarian cysts are: simple renal cysts, multicystic dysplastic kidney, hydronephrosis, ureterocele, uracal cysts, hydrocolpos, enteric cystic duplications, meconial pseudocysts, lymphangiomas, fetus in fetu. Each of these entities presented specific ultrasonographic and MRI characteristics (both pre-and postnatally) that usually allow a correct diagnosis.
Clinical evolution
Following the prenatal diagnosis of ovarian cyst, an ultrasound (US) follow up is indicated until delivery to monitor any changes in the size and/or echogenicity of the cyst. US timing is established according to the diameter and the characteristics of the lesion.
As reported in literature, the size of the cyst correlate both with the risk of fetal ovarian torsion and with the rate of spontaneous resolution. Even if there is no clear consensus on a defined diameter (in different studies diameters from 3 to 6 cm are considered as cut-off), it can be assumed that simple cysts ≤4cm will undergo more frequently complete regression during prenatal or postnatal period; while simple cysts >4cm more frequently are associated with torsion or with postnatal surgery.3,10,14,15 Moreover, most complications of fetal ovarian cysts (intracystic hemorrhage, necrosis, adhesions, compression of the surrounding organs, infertility, etc.) are due to the torsion itself. Because of that, simple cysts >4 cm, or with a growth of more than 1 cm per week, have to be monitored very closely and fetal aspiration could be considered. 3,10
Changes in US pattern of the cyst during follow up are associated with an increased risk of ovarian loss (autoamputation or postnatal surgical removal).16
Complicated cysts have a significant lower rate of spontaneous resolution compared to simple cysts. Nonetheless, they could not be considered an indication for preterm labor: the torsion event usually has an undefined duration and the loss of ipsilateral ovarian function cannot be correlated to the time of delivery.
Considering simple ovarian cysts, conservative postnatal management (clinical and US follow up) is suggested since most of them may undergo spontaneous regression. Postnatal US scans can be scheduled every 3-6 weeks according to the diameter and the characteristics of the lesion. US follow up is continued until cyst regression or until the appearance of complications (size increase, torsion) or, if the lesion persists, until the age of 6 month.12
The risk of having postnatal surgery is higher in cysts >4cm compared with those ≤4cm and in complex cysts compared to simple ones (irrespective of the cyst size).16
If an increase in cyst size is observed, clinical symptoms develop or the cyst persist beyond 6 months, an operative approach is indicated to reach a correct diagnosis.17
Operative treatment of ovarian cyst could offers several options: non-surgical (aspiration reserved to simple ovarian cysts) or surgical (derotation, deroofing, cystectomy, oophorectomy, salpingo-oophorectomy). Considering the single hospital attitude and experience, surgery can be performed with a minimally invasive approach or with a traditional open approach. Laparoscopic surgery has proved to be feasible and safe in cases of neonatal ovarian cysts, and in centers of expertise, should be considered as first approach.12,18
Treatment
Prenatal treatment (Figure 3)
The risk of fetal ovarian torsion has led several groups to perform ultrasound-guided prenatal aspiration in cases of large simple ovarian cysts.4
However, it is mandatory to balance the benefits of this maneuver with the potential risks of complications as bleeding and uterine contractions that can lead to preterm delivery.
To date, there is a low level of evidence in literature about the efficacy and safety of prenatal ovarian cysts aspiration. Different authors reported that simple cysts with a diameter larger than 3 or 4 or 5 cm (depending on author) had lower rates of torsion when aspirated prenatally and lower rates of postnatal surgery (in particular postnatal oophorectomy) compared to same size cysts conservatively managed.3,15,19-22
Waiting for a wider consensus, we want to highlight the need to provide mothers with excellent information and communications from physician responsible of the procedure.
Postnatal treatment (Figure 4)
In the case of simple ovarian cysts, conservative postnatal management consists in a clinical and US follow up since the cysts may spontaneously regress. Postnatal ultrasound scans can be scheduled every 3-6 weeks until cyst regression.
We can resume indications to post-natal treatment to: i) Complex cysts (diagnostic definition); ii) Symptomatic cysts (suspected torsion); iii) Simple cysts complicating their aspect during postnatal US follow up (suspected torsion); iv) Simple cysts growing more than 4 cm during postnatal US follow up (improved risk of torsion); v) Simple cysts persisting over the age of 6 months (diagnostic definition).
As said before, there is no clear consensus on diameter cut off.
Postnatal treatment can offer different options.
US-guided cyst aspiration
There is few literature about this procedure: some authors proposed US-guided percutaneous aspiration as the treatment of choice for simple neonatal ovarian cysts, limiting surgical exploration as much as possible;27 others questioned the efficacy of aspiration during neonatal period since there are no extensive studies on the subject;21 some studies have shown the need for a second puncture to obtain a complete evacuation of the cyst, therefore even in cases of postnatal aspiration an ultrasound follow-up period is usually indicated.28
In conclusion, advantages of this procedure could be considered effectiveness and repeatability, moreover some authors suggest that this procedure preserve ovarian tissue in a higher percentage of patient than surgery.26-28 Nonetheless some reports question US diagnostic accuracy and the risk to puncture different lesions than ovarian cysts (e.g. enteric duplication).29
Surgical approach
If ovarian torsion occurs during post-natal follow-up, a surgical attempt at ovarian de-torsion must be undertaken to spare the ovary even if the pedicle is usually very thin. Oophorectomy and/or salpingo-oophorectomy should be reserved to those cases of irreversible ovarian necrosis or in which torsion places the patient at risk of sepsis, or hemodynamic instability.
Usually, the presence of complex ovarian cysts indicates the need for surgical exploration: some authors proposes surgical excision in case of neoplastic suspicion, in cases of complex ovarian cysts and when simple cysts remain unchanged for more than 6 months.10,32,33 However, the finding of complex ovarian cysts does not place an absolute indication to surgery:3,34 authors reported a spontaneous tendency towards involution of twisted ovarian cysts, concluding that conservative treatment of such cysts may represent a therapeutic option and that surgery should be reserved for particularly large lesions (when it results in an intra-abdominal mass effect) or those that do not tend to involve.4
However, conservative treatment of complex ovarian cysts, however, does not reduce the risks of possible complications, which, although rare, have important clinical implications:21 there are several publications reporting the correlation between intracystic hemorrhage and development of fetal, or neonatal, anemia requiring transfusion therapy;35,36 moreover postnatal intestinal obstruction caused by complex ovarian cysts is also described: the presence of self-amputated ovarian cysts can cause inflammation and intestinal adhesions (the risk of intestinal obstruction due to amputated cysts has not been compared to that caused by laparoscopic exploration, and there are divergent opinions on this aspect).37-39
When surgery is needed, different minimally invasive techniques are described to approach neonatal ovarian cyst: open (transumbilical approach); videoassisted technique (one trocar); laparoscopic (three trocars).40-44
As described in literature, all these minimally invasive approaches have to be considered diagnostic and therapeutic. They are safe and effective, operation time and length of hospital stay are short and cosmetic appearance after surgery is good.
It is important to remind that intraperitoneal spillage of cystic liquid could happen during these procedures, so it is important to exclude a neoplastic lesion before surgery (even if they are extremely rare in neonatal period).
Before the operation, a nasogastric tube is positioned and the cleaning of the bowel with one or more enema is recommended:
- Transumbilical technique: because of the long ovarian pedicle, which consent a good mobility, and the frequent intrabdominal position of the neonatal ovarian cyst, it is possible to manage the lesion through a transumbilical route. A semicircular infraumbilical incision (according to Bianchi) is made, the fascia is longitudinally incised and the abdomen is entered. The cystic surface is then exposed through the incision and the liquid content is aspired by a needle (it is recommended to send a sample to cytological analysis). The partially collapsed cyst is then exteriorized for derotation/deroofing/cystectomy/oophorectomy/salpingooophorectomy.
- Video-assisted technique: through a trans or infra-umbilical incision a 5 or 10mm 30° laparoscope with operative channel is inserted in the abdominal cavity and pneumoperitoneum is induced up to 6mmHg. Ovarian cyst is then visualized and have to be aspirated. Aspiration could be performed with different techniques: thanks to the operative trocar the cyst could be mobilized and expose through the umbilical incision to proceed aspiration and surgery as described for the transumbilical approach. Alternatively, the ovarian cyst is approached to the abdominal wall thanks to a forceps, and, under laparoscopic control, a needle is inserted through the abdominal wall to aspire the cyst; the cyst partially collapsed is then exteriorized through the umbilical incision and procedure is completed as described before.
- Laparoscopic technique: a 3 or 5 mm 30° laparoscope is inserted through a transumbilical incision; pneumoperitoneum induced up to 6mmHg; two 3mm operative trocars are positioned under direct vision in right and left hypochondriac regions (according the triangulation and the position of the cyst that could be not necessarily in the pelvis ).If a torsion is diagnosed, the ovary is de-rotate thanks to the operative instruments. To aspire the cyst is possible to incise its surface with a Crochet hook needle and insert through this incision an endoscopic aspirator to empty the cyst. Then is possible to proceed laparoscopically with deroofing/ cystectomy/oophorectomy/salpingo.oophorectomy.
Conclusions
As final recommendations, the evidence currently available on the diagnosis and treatment of fetal ovarian cysts observed in prenatal and postnatal life is very limited, since no randomized studies are available on any aspect of this entity. Often the indications for treatment derive from revisions of small monocentric case studies. Nevertheless, we can conclude that prenatal treatment with ultrasound-guided puncture of simple ovarian cysts >40 mm seems to be related to a significant benefit in terms of preservation of the ovarian parenchyma. Postnatal surgical approach in cases complicated by ovarian torsion appears to be useful to safeguarding the residual ovarian parenchyma and preventing possible complications secondary to ovarian torsion, as shown in the flowchart.