Articles
30 June 2014
Vol. 36 No. 3 (2014)
https://doi.org/10.4081/pmc.2014.11

Precocious puberty in a patient with Oculo-Auriculo-Verebral spectrum (OAVS)

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Oculo- auriculo- vertebral spectrum. Precocious puberty. Neural crest cells
1278
Views
1223
Downloads

Authors

A. Berio
agostinoberio@ospedale-gaslini.ge.it
Dipartimento DINOGMI Università di Genova, Genova, Italy.
G. Garlaschi
Dipartimento DISSAL Università di Genova, Genova, Italy.
A. Piazzi
Dipartimento DINOGMI Università di Genova, Genova, Italy.
The authors report on the first case of OAVS (Oculo-Auriculo- Vertebral-Spectrum), with hemifacial microsomy, hydrocephalus, pubertas precox, thelarche at 4 years of age, vaginal bleeding at 5 years, and left ovary of adult type on echography (right ovary initially not visualized). FISH and CGH-ARRAYS methods were negative. By GnRH therapy the delay of onset puberty was obtained. The authors ascribe facial and ovary asymmetry to a derangement of blastogenesis, during which axial right-left structures begin the develop with consequent migration or interation with surrounding tissues of neural crest cells and alteration of diencephalic pituitary systems.

Altmetrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite



Precocious puberty in a patient with Oculo-Auriculo-Verebral spectrum (OAVS). (2014). La Pediatria Medica E Chirurgica, 36(3). https://doi.org/10.4081/pmc.2014.11

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.