Nutritional and metabolic programming during the first thousand days of life


Submitted: 7 June 2017
Accepted: 26 June 2017
Published: 28 June 2017
Abstract Views: 10958
PDF: 6077
HTML: 1345
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The latest scientific acquisitions are demonstrating what has already been hypothesized for more than twenty years about the development of the state of health/illness of individuals. Indeed, certain stimuli, if applied to a sensible phase of development, are able to modify, through epigenetic mechanisms, gene expression of DNA, resulting in adaptive modifications of phenotype to the environment, which may reflect negatively on the health of every individual. This concept, applied to nutrition, has opened up important prospects for research in this area. The nutritional history of an individual, linked to the development of a healthy state, would begin very early. In fact, since the pregnancy and for the next two years (for a total of about 1000 days), the maternal eating habits, the type of breastfeeding and then the main stages of nutrition in the evolutionary phase represent those sensitive moments, essential for the development of important endocrine, metabolic, immunological alterations, better known as metabolic syndrome. This condition would represent the physiopathogenetic basis for explaining a series of disorders, known as non communicable diseases (NCDs) such as obesity, diabetes, hypertension, cardiovascolar disease and all those conditions that today affect the health of most industrialized countries and through the years are emerging especially in developing countries (South America, Asia), where new environmental conditions and increased food availability are changing food habits, with far-reaching public health impacts. This paper analyzes these new nutritional perspectives and the main implications of what has been termed the 1000-day theory.

Massimo Agosti, Neonatal Intensive Care Unit, University Hospital Del Ponte, Varese
S.C. Neonatologia, Terapia Intensiva Neonatale e Pediatria Verbano
Francesco Tandoi, Neonatal Intensive Care Unit, University Hospital Del Ponte, Varese
S.C. Neonatologia, Terapia Intensiva Neonatale e Pediatria Verbano
Laura Morlacchi, Neonatal Intensive Care Unit, University Hospital Del Ponte, Varese
S.C. Neonatologia, Terapia Intensiva Neonatale e Pediatria Verbano
Angela Bossi, Neonatal Intensive Care Unit, University Hospital Del Ponte, Varese
S.C. Neonatologia, Terapia Intensiva Neonatale e Pediatria Verbano

Supporting Agencies

Merqurio Editore

Agosti, M., Tandoi, F., Morlacchi, L., & Bossi, A. (2017). Nutritional and metabolic programming during the first thousand days of life. La Pediatria Medica E Chirurgica, 39(2). https://doi.org/10.4081/pmc.2017.157

Downloads

Download data is not yet available.

Citations